These include changes in the composition of circulating metabolites, proteins and cell free DNA, which can be sampled through a liquid biopsy, providing an avenue for non-invasive routine monitoring. The progression to advanced cancer is accompanied by the appearance of molecular alterations over time. By detecting these events earlier, new treatment windows become possible to truncate progression to advanced cancer, potentially achieving cure. Limited by current tools and detection methods, doctors react to these events after advanced or treatment refractory disease has developed. During a patient’s journey with cancer, metastases, treatment failure & therapy resistance can develop, leading to advanced disease and potentially death. Single-Cell In Situ Spatial Omics at Subceullar ResolutionĬaLiBRe (Cancer Liquid Biopsies for Real-time diagnostics and early intervention) is an end-to-end national cancer liquid biopsy program that seeks to use multi-modal profiling of liquid biopsies and data analytics to transform cancer care.Ĭancer is a chronic disease.Spatial and Single Cell Genomics Platform.Epigenetic And Epitranscriptomic Regulation.Precision Medicine And Population Genomics.Post Doctoral Fellows and Research Associate.Junior Principal Investigator / GIS Fellows.

Calibre program